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KMID : 0604520190450030287
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Journal of the Society of Cosmetic Scientists of Korea
2019 Volume.45 No. 3 p.287 ~ p.297
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Studies on Antioxidant, Anti-inflammation and Whitening Activities of Hordeum vulgare L. Extracts and Their Fractions
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Park Che-Hwon
Park Jang-Ho
Min Seon-Young
Kim Kyung-Min
Kim Su-Yeong
Park Young-Jin
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Abstract
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This study was carried out to evaluate the antioxidant, anti-inflammation, and whitening effect of Hordeum vulgare L. extracts and their fractions. Total polyphenol and flavonoid contents in fractions were varied from 13.58 to 40.06 mg GAE/g and 7.67 ∼ 13.67 mg CE/g, respectively. Among the three fractions(chloroform, hexane, and water), 400 μg/mL of the chroloform fraction showed similar antioxidant activity to ascorbic acid (30 μM) against the 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical. The chloroform and hexane fractions inhibited the NO production of RAW 264.7 cells similar to quercetin (15 μM) and the chloroform fraction of 100 μg/mL significantly reduced IL-6, iNOS and COX2 gene expression. Additionally, the chloroform fraction inhibited β-hexosaminidase degranulation, IL-4, and IL-13 gene expression in RBL-2H3 cells. All of the fractions inhibited tyrosinase activity in a concentration-dependent manner, and the hexane fraction at 50 μg/mL and the chloroform fraction at 100 μg/mL significantly inhibited melanin production of B16F10 cells. These results indicated that H. vulgare L. can be used as an effective cosmetic ingredient having anti-inflammation and whitening activity.
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KEYWORD
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antioxidant, anti-inflammation, tyrosinase, Hordeum vulgare L., whitening activity
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